Local food banks, money advice services and community clothing projects are to benefit from £10 million of lottery funding.
The scheme launched by the Big Lottery Fund (BIG) will run over the next two years and aims to improve local support for people experiencing hardship.
The new Support and Connect fund, now open to applications, also offers support to lunch and breakfast clubs and organisations helping to address fuel poverty.
Maureen McGinn, BIG committee chair, said: "Across the country we see families and communities in difficulty, dealing with greater challenges, many of them struggling to cope with the financial, emotional and physical pressures of day-to-day life.
"Enabling people to navigate these challenges is at the heart of our work at BIG. As part of our response, we are making £10 million available over the next two years for our Support and Connect fund.
"This new fund is designed to do two things: improve local support for people experiencing tough times, as well as assisting organisations working within communities to deliver support in a more joined-up way so that everyone can get the help they need."